Assessment of histopathological and histochemical changes in liver of pregnant female rats and their fetuses following ciprofloxacin administration

The present study was carried out on female albino rats weighing 130-160 g, through two periods of gestation [day 1 or day 6 up to day 19 of pregnancy] representing four experimental groups and one control group. Experimental animals were given daily oral dose [57 mg/Kg b.w., therapeutic dose] or 114 mg/K b.w. [double therapeutic dose] of ciprofloxacin [CPFX]. Dissection was performed on day 20 of pregnancy. Histological changes in liver sections of pregnant rats were in the form of dilatation of central and portal vein, and sinusoidal spaces; appearance of macrophages and Kupffer cells in sinusoidal spaces and congestion in blood vessels, The hepatocytes showed cytoplasmic vacuolation and nuclear unrest, Inflammatory leucocytic infiltration and focal fibrosis were also observed. Liver sections of fetuses obtained from pregnant rats treated with the [CPFX] revealed histopathological alterations similar to their mothers. Total proteins content decreased by -5.59% in GI, -8.60% in GIII and -6.83% in GIV. Group two [GII] recorded a lower level in total protein [-0.62%]. Moreover a significant decrease in total protein of fetuses was manifested being 17.96%, 13.28%, 22.62% and 21.87% for the four groups, respectively. The hepatocytes of mothers exhibited a significant decrease in DNA content presenting 9.42%, 3.46%, 10.40% and 7.51,% in the four groups respectively. In the hepatocytes of their fetuses the DNA content recorded a significant decrease of 10.43%, 9.34%, 18.68% and 17.58% for the four groups respectively. These results emphasize the toxicity of CPFX and its teratogenic effects

Histological changes induced by feeding on fried potato and protective role of curcumin in the liver of female rats and their offsprings

This study deals with the evaluation of the histological effect of feeding on fried potato and the protective role of curcumin on the liver of pregnant rats and their offspring. The results showed that the using of fried potato caused different histopathological lesions in the liver of female rats and their offspring. These lesions include vacuolated cytoplasm, dilated blood vessels, congested blood vessels, haemorrhage, pyknosis, necrosis and complete degenerated areas. The emerged data showed that fried potato induced histological alterations in the liver of rats similar to those caused due to acrylamide in food. The present findings suggested that curcumin have no protective effect against the degenerative effect of fried potato